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One North Carolina Small Business Program Logo

The One North Carolina Small Business Program is comprised of two programs:

  • The SBIR/STTR Phase I Incentive Funds Program - As authorized by NC General Statute § 143B‑437.80, awards reimbursement to qualified NC businesses for a portion of the costs incurred in preparing and submitting Phase I Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) proposals to federal agencies. The goals are to increase the number, quality, company and technology diversity, and geographic breadth of NC applications for Federal SBIR and STTR Phase I awards.
  • The SBIR/STTR Phase I Matching Funds Program - As authorized by NC General Statute § 143B‑437.81, awards matching funds to NC businesses who have received a federal SBIR or STTR award. The goals are to help NC companies bridge the funding gap period between the final Phase I payment and the first Phase II payment in the Federal Program, and increase the intensity of the research conducted under Phase I, making NC small businesses more competitive in the competition for Phase II funds.

For additional information regarding solicitations, see Current Solicitation & Guidelines or Previous Solicitations & Awardees below.

The NC FY 2024 solicitations of One North Carolina Small Business Program remain open until June 30, 2024, or until funds are exhausted (Note: Funds remain but may run out soon; apply ASAP)

Tab/Accordion Items

Before applying to the program(s), please review the current solicitations, particularly the information on page 2 regarding the Solicitation Period, Key Dates, and Maximum Grant Amount and Eligible Applicants.

For current solicitations (which apply to a specific time period, such as a state fiscal year), see:

The NC FY 2024 solicitations of One North Carolina Small Business Program remain open until June 30, 2024, or until funds are exhausted (Note: Funds remain but may run out soon; apply ASAP).  

For general program guidelines (which are more general and overarching than specific Program Solicitations and govern the administration of the Programs on an ongoing basis), see:

If you have questions, please contact the OSTI staff.

Online webinar, hosted by the Small Business & Technology Development Center (SBTDC) and featuring Office of Science, Technology & Innovation (OSTI) staff, on November 29, 2023.


  • FY 2024 One North Carolina Small Business Program Details
  • Application Tutorial begins 26:19
  • Q & A begins 43:05

Access video at GoTo Webinar.
Note: Video is free, but you must register to access it.

Applications for the One North Carolina Small Business Program are managed through the CyberGrants Management System. To start a new application for the Program under the FY 2024 Solicitations, access the CyberGrants Management System using the links below. Review the solicitations before applying.

Start a New Phase I SBIR/STTR Incentive Funds Application

Start a new Phase I SBIR Matching Funds Application

Start a New Phase I STTR Matching Funds Application

If you have questions regarding the programs overall or eligibility, please contact the OSTI staff.

Reports and Applications for the One North Carolina Small Business Program are managed through the CyberGrants Management System.

To submit reports or a survey, or to edit an already active application for the Program, access the CyberGrants Management System using the links below:

If you are ready to request a Stage 2 payment disbursement, please contact the OSTI staff.

Program Impacts

A detailed analysis of the One NC Small Business Matching Funds Program impacts is conducted every two years. The most recent evaluation found that, since its inception in 2006, the program has helped enable:

  • the creation and retention of more than 1,200 private sector jobs statewide – more to come as more companies benefit and grow.
  • more than 400 small businesses bring to market biotechnology, nanotechnology, medical technologies, computer software, military/defense technologies, pharmaceuticals, textiles, and other high-tech applications.
  • more than 70 percent of the small businesses to remain in operation.
  • the small businesses to attract more than $8 billion in external investment.
  • 60 percent of NC matching grant winners to win Phase II federal grant awards, each with a considerably larger average value of $1 million (nationally, 54 percent of Phase I award winners graduate to Phase II awards).
  • the small businesses to produce more than $125 million in total first-year sales resulting directly from the technology developed with Program funding.
  • significant technology/business-development partnerships among NC universities & businesses.

For a printable two-page summary of the strong impacts of the One NC Small Business Program since its inception in 2006, see:


Success Stories

  • Applied LifeSciences & Systems (Raleigh) - Biosystems Company Builds Technology That Reduces Business Costs & Improves Animal Welfare
  • Baebies (Durham) - Innovating a Healthy Start for Babies and a Diagnostic Company
  • Bennett Aerospace (Cary) - Smart Engineering Creates New Products & A Successful Company
  • Corvid Technologies (Mooresville) - One North Carolina Small Business Program Supports Engineering Firm's Overwhelming Growth
  • Precision BioSciences (Durham) - Cutting-Edge Leadership in a New Technology Can Cut Both Ways
  • Prevention Strategies (Greensboro) - Preventing Bad Behavior Alone Doesn't Lead to Business Success
  • Ribometrix (Durham) - Innovative Treatment Strategy for Human Disease Shapes a Successful Biotech Company
  • United Protective Technologies (Locust) - Thin Coatings Protect Military Investments and Facilitate Small Business Growth
  • Vigilant CyberSystems (Mt. Airy) - Surviving Threats in Cyberspace and The Tough World of Business

Since its inception in 2006, the program has awarded Phase I SBIR/STTR Incentive and Matching grants to 434  small businesses throughout the state. Those businesses are listed below; links to their websites are provided when available. Additional detail regarding awards made to these small businesses is available in the Previous Solicitations & Awardees section below.

0 Base Design, LLC

3-C Institute for Social Development, Inc.


3TEX, Inc.

410 Medical, Inc.

4pi Analysis, Inc.


A-B-Sea Research

AccuNovo Biotechnologies, Inc.

Adamas Nanotechnologies, Inc.

Admet Technologies

Adroit Materials

Advanced Digital Systems, Inc.

Advanced Hydrogen Technologies Corporation

Advanced Liquid Logic, Inc.

Advanced Materials Manufacturing

Advanced TeleCare, LLC


Aegis Power Systems, Inc.

Affinergy, Inc.

Affinergy, LLC

Agile Sciences, Inc.

AI Tracking Solutions, LLC

AimMax Therapeutics, Inc.

Air Control Techniques, P.C.

Airilabs Inc.


Akoustis, Inc.

Alderon Biosciences, Inc. 

Alditri Technologies, Inc.

Algaen Corporation 

Allotropica Technologies, Inc.

Altis Biosystems, Inc.

Altometrics, Inc.

Ambient Logic

Amissa, Inc.

AP Solutions, Inc.

Appealing Products, Inc.

Applied LifeSciences & Systems

Applied Quantum Technologies, Inc.

Applied Research Transformation, PLLC

Applied Science International, LLC

Arcato Laboratories, Inc.

Archimedes Analytical, LLC

Arctic, Inc.

ArrayXpress, Inc.


Artiam Bio, Inc.

Askew Energy

Asklepios BioPharmaceutical, Inc.

Assist Equipment Development, Inc.

Athena's Compass

Atlantic Fish Co.

Atom Bioworks, Inc.

Auger Communications, Inc.

AURA Technologies, LLC


AxNano, LLC

b3 bio, Inc.

Baebies, Inc.

Bear Fiber, Inc.

Bedrock Therapeutics


Bennett Aerospace, LLC

Bennett Aerospace, Inc.

Biofluidica, Inc.

Biographics, Inc.

BioKier, Inc.

BioLink Life Sciences, Inc. 

BioMarck Pharmaceuticals

BioMedomics, Inc.

Biomodal, LLC

BioMojo, LLC

Bioptigen, Inc.

Black Velvet Solar, Inc.

Blue Force Technologies, Inc.

Blue Ridge Research and Consulting, LLC

BotaniPharm, LLC

Boundless Science, LLC

Branelie Health, Inc.

Brighton Development, LLC

Broad Digital, LLC

Callahan-Young, LLC

Camras Vision, Inc.

Capture Pharmaceutical, Inc.

Carolina Unmanned Vehicles, Inc.

Catalytic and Redox Solutions, LLC

CD Neural Technologies

Cell Microsystems

Celldom, Inc.

CellF Bio, LLC


Chaperone Therapeutics, Inc.

Cirque Productions, LLC

CivaTech Oncology, Inc.

CiVentiChem, LLC


Clairvoyant Technology, LLC

Claradele Pharmaceuticals, Inc.

Clinical Sensors, Inc.

Clinical Tools, Inc.

Cloud Solutions, LLC

Cognosci, Inc.

Collaborations Pharmaceuticals, Inc.

ColoWrap, LLC

Construkts, Inc.

Converter Source, LLC

Coprata, Inc.

Corvid Technologies, LLC

Cosmic Eats, Inc.

CP Diagnositics, Inc.

Creative Bioreactor Designs, Inc.

Creative Scientist, Inc.

CryoFacets, Inc. 

CTW Development Company, LLC


Cycle 9, LLC

Cytex Therapeutics, Inc.

Daheco Engines & Energy

Daimler Devices

Deep Creek Pharma, LLC

Digital Health Navigation Solutions

Dignify Therapeutics, LLC

Dot Metrics Technologies, Inc.

Drakeford, Scott, & Associates, LLC

Drive Therapeutics, LLC

E-Sentience, LLC

Edison Agrosciences

Educational Consultation and Development, Inc.

ELDEC Pharmaceuticals, Inc.


Element Genomics, Inc.

Empower Healthware Inc.

EncepHeal Therapeutics

Endacea, Inc.

EnergyXchain, LLC

Enformia, Inc.

Enfuego Therapeutics, Inc.

Eno River Labs, LLC

Eno River Technologies Co., LLC

EnSolve Biosystems, Inc.

Entertainment Science & Virtual Heroes Joint Venture

Enzerna Biosciences, Inc.

EpiCypher, Inc. 

Epigenos Biosciences, Inc.

Eppin Pharma, Inc.

Ercole Biotech

ExLattice, Inc.

EydisBio, Inc.

Eyedesis Biosciences

F&I Enterprises, LLC

Falcon Therapeutics, Inc.

Firebird Advanced Materials, Inc.

Flexcell International Corporation

Foard Systems Design, Inc. 

Fokuslabs Behavioral Solutions, Inc.

ForesightCares, Inc.

Forthright Engineering, PLLC

Franklin Scientific Corporation

Freescale, LLC

FutureNow Technologies

G-Zero Therapeutics, Inc.

Galaxy Diagnostics, Inc.

GEM Tox Consultants and Labs, Inc.

Geometric Data Analytics

Gigabeam Acquisition Corporation

Glycan Therapeutics Corporation

Goldfinch Sensor Technologies and Analytics, LLC

Gradient Medical

GrassRoots Biotechnology, Inc.

GreatWall Systems, Inc. 

GreenLifeTech Corporation

GridBridge, Inc.

GTCAllison, LLC

Haw River Mushrooms, LLC

Health Outcomes, Inc. 

HealthSpan Diagnostics, LLC

HepatoSys, Inc.


Horizon Performance

Humacyte, Inc.

Hydrosize Technologies

Identizyme Defense Technologies, Inc.

iEdapts, LLC

Immunobiosciences, Inc.

Impulse Wellness, LLC


Inanovate, Inc.

Independent Living Resources, Inc.

Indexus Biomedical, LLC

IngateyGen, LLC

Initos Pharmaceuticals


InnAVasc Medical, Inc.

InnerOptic Technology, Inc.

InnovaTech, Inc.

Innovation Research and Training, Inc.

Innovation Therapies

Innovative Viral Solutions, LLC

Insect Diet and Rearing Research, LLC

Insightfinder, Inc.

InsituTec, Inc.

inSoma Bio, Inc.

Integrated Laboratory Systems, Inc. (ILS)

Integrated Oncology Solutions, Inc.

Intelli-Products, Inc.

Intermodal Logistics Consulting, Inc.

International Association of Virtual Organizations, Inc.

Interventional AnalgesiX, Inc.

Isolere Bio, Inc

Jenken Biosciences, Inc.

Keona Health

Kepley Biosystems, Inc.

KeraNetics, LLC

Kyma Technologies, Inc.

LaamScience, Inc.

Laser Biopsy, Inc.

LED Radiofluidics Corp.

LifeSciTech, LLC

Liquidia Technologies, Inc.

LiRA, Inc.

Lloyd Technologies, Inc.

LUBA Corporation

Lumedica, Inc.


Lupine Materials and Technology (LMT)

MAA Laboratories

Mammae Biosciences, Inc.

ManningRF, LLC

Markeyia Tech, LLC 

Materials Innovation Technologies

Maverick BioFuels, Inc.

Mercury Science, Inc.

Metalytics, LLC

METIS Health Analytics, LLC

MicroElastic Ultrasound Systems, Inc.

Microgrid Labs, Inc.

Microphase Coatings, Inc. 

Mimetics, LLC

Minerva Lithium, LLC

MMC Productions, Inc.

Moires Instruments

Morphormics, Inc.

MoveableCode, Inc.

MRI Cardiac Services, Inc.

MRPath, Inc.

MSI Software Solutions, LLC

Mucommune, LLC

Multi3D, Inc.

Murano Corporation

MuukLabs, Inc.

Mycologics, LLC

Mycosynthetix, Inc.

NabGen, Inc.

Nanodiagnostic Technology, LLC

Nanolytics, Inc.

Nanomics Biosciences, Inc.

NanoTechLabs, Inc.

NanoVector, Inc.

NCO Technologies, LLC

Nekton Research, LLC

Neuro10-9 Pharma, Inc.

Neurocog Trials, Inc.

NeuroGT, Inc.

New Jersey Microsystems, Inc.

NextPower360 Co.

NextRay, Inc.

NIRvana Pharmaceuticals, Inc.

Nirvana Sciences, Inc.

Nitronex Corporation

Nocturnal Product Development

Noor Brands Company, LLC

Novan, Inc.

NovaTarg, Inc.

Nuvotronics, Inc.

Olfax, LLC

Om Bharti, LLC

Oncoscope, Inc.

OncoTAb, Inc.

Oncotrap, Inc.

Oncurie, Inc.

Onda Vision Technologies, Inc.


OpSource, Inc. 

Optera, LLC

Optopo, Inc.


Orbit Energy, Inc.

Oxford Defense North Carolina, LLC

Pareto Games (Silver Springs, LLC)

Parion Sciences

Patagonia Health, Inc.

Path BioAnalytics, Inc.

People Designs, Inc

Perfusio Corp.

Perotech, Inc.

PestStop, LLC

PharmaSys, Inc.

Phase, Inc.

Phaxtec, Inc.

PhotoCide Protection, Inc.


Physcient, Inc. 

Piedmont Biofuels Industrial

Plakous Therapeutics, Inc.

Plureon Corporation

Polarean, Inc.

Polyglot Systems, Inc.


Practical Scientific Solutions, Inc.

Praetego, Inc.

Precision BioSciences

Precision Human Biolaboratory Inc. (Ridge Diagnostics)

Predictive, LLC

Premitec, Inc.

Prevention Strategies, LLC

PrimeNeuro, Inc.

Prohuman Technologies

Protochips, Inc.

Provagen, Inc.

Proventys, Inc.

Proximal, LLC

Pulvinar Neuro, LLC

Puratec, LLC

Qatch Technologies, LLC

Qualiber, Inc.

Quantworks, Inc.

QuarTek Corporation

Rachel Miller

Raglan, LLC

Ramona Optics, Inc.

Redbud Labs, Inc.

Regennova, Inc.

Religent, Inc.

Rescindo Therapeutics, Inc.

Reselute, Inc.

Resolved Analytics, PLLC

Reveris Therapeutics, LLC

Ribometrix, Inc.

Ribometrix, LLC

Rivis, Inc.

Roundtable Analytics, Inc.

rPath, Inc.

Saha Pharmaceuticals, Inc.

Science Learning Resources, Inc.

SciKon Innovation, Inc.

ScitoVation, LLC

Scribner Associates, Inc.

SeaTox Research, Inc.

Secmation, LLC

Selsym Biotech, Inc.

Semprius, Inc.

Setter Research, Inc.

SeventhDigit Corporation

Signal Innovations Group, Inc.

Sindre Metals, Inc.

SinnovaTek, Inc.

Sirga Advanced Biopharma, Inc.


Smart Material Solutions, Inc.

Social Cascade, LLC

Soelect, Inc.

Solitronics, LLC

SonoVascular, Inc.


Southeast TechInventures, Inc. 

SoyMeds, Inc.

Stovall Life Science, Inc.

STRAD Corporation

Stratus Technolgy Group, LLC

Studio Hagler, LLC

Sun Dance Genetics, LLC

SunCastle Microwave, LLC

SureMilk, LLC

Susteon, Inc.

Symberix, Inc.

Blazegraph (SYSTAP, LLC)

Technical Designs, Inc.

TeleSage Research, Inc.

TeleSwivel, LLC

Telli Technologies

Tellus Therapeutics

Endivica bio (Tensive Controls, Inc)

Teotten Diagnostics

The Myvatar Company

The Sandbox Learning Company

Theia Imaging

TheraBrux LLC

TheraLogics, Inc. 

ThinkZone, LLC

Third Floor Materials, Inc.

Treadwell Corporation

Triad Interactive Media, Inc.

Triad Semiconductor, Inc.

Triangle BioSystems, Inc.

Triangle Biotechnology, Inc.

Triangle Environmental Health Initiative 

Triangle Polymer Technologies, Inc.

Triangle Precision Diagnostics, Inc.

TriboFilm Research, Inc.

United Nano Works

United Protective Technologies, LLC

Upstream Biotechnology, Inc.

US Environmental Protection Service


Vadum, Inc.

Valencell, Inc.

Vascular Biosciences

Vascular Pharmaceuticals, Inc.

Venti, LLC

VeritasCNC, Inc.

Versametrics, LLC

Vesta Therapeutics

VetOncoDx, LLC

Video Collaboratory, LLC

Vidterra, LLC

Vigilant Cyber Systems, Inc.

Virtual Heroes, Inc.

Virtual Reality Aids, Inc.

Vizma Life Sciences

Vortant Technologies, LLC

Voxel Innovations

Wasatch Photonics, Inc.

Wave Computation Technologies, Inc.


Wisely, Inc.

WISER Systems, Inc.

X-In8 Biologicals Corporation

Xintek, Inc.

ZellComp, Inc.

Zen-Bio, Inc.

Zenalux Biomedical

Zumatek, Inc.

Zymeron Corporation

The One North Carolina Small Business Program helps small businesses develop and commercialize innovative technologies to benefit the general population. In the process, it helps high-tech businesses attract more funding to the state―keeping home-grown technologies in North Carolina and creating more well-paying jobs.

Previous solicitations and listings of awardee small businesses under the Matching Funds Program and Incentive Funds Program are available for download in the tables below.

Matching Funds Program

Note: Program was not funded in FY 2020, FY 2018, FY 2014, FY 2013, or FY 2012. 
Solicitations and new awards were not available during those Fiscal Years.

Fiscal Year Solicitation Award # Award $ Awardees
FY 2023 Solicitation 25 $1,702,859 Awardees
FY 2022 Solicitation 67 $4,660,090 Awardees
FY 2021 Solicitation 29 $1,500,000 Awardees
FY 2019 Solicitation 25 $1,201,990 Awardees
FY 2017 Solicitation 62 $3,686,680 Awardees
FY 2016 Solicitation 40 $1,954,004 Awardees
FY 2015 Solicitation 51 $2,500,000 Awardees
FY 2011 Solicitation 44 $1,311,513 Awardees
FY 2010 Solicitation 22 $1,018,940 Awardees
FY 2009 Solicitation 54 $3,968,589 Awardees
FY 2008 Solicitation 49 $4,675,952 Awardees
FY 2007 Solicitation 51 $4,553,918 Awardees
FY 2006 Solicitation 25 $1,111,817 Awardees
Total   544 34,299,021 All Awardees

Incentive Funds Program

Note: Program was not operational between FY  2010-2021 or FY 2006-2007.
Solicitations and new awards were not available during those Fiscal Years.

Fiscal Year Solicitation Award # Award $ Awardees
FY 2023 Solicitation 48 $345,562 Awardees
FY 2022 Solicitation 50 $308,143 Coming soon
FY 2009 Solicitation 53 $156,041 Awardees
FY 2008 Solicitation 37 $107,241 Awardees
Total   188 $916,986 Coming Soon

If you have questions, please contact the OSTI staff.

The Board of Science, Technology & Innovation provides annual reports on the One North Carolina Small Business Program to the North Carolina General Assembly, as required by North Carolina General Statute § 143B‑437.83.

Copies of these reports are publicly available through the links below:

If you have questions, please contact the OSTI staff.